3cc per leg, straight, not diluted. If I know they're itching down low around the pasterns I'll put it in that area. If they are itching up higher (usually they'll itch on the feed tubs) then I'll place it up higher in that area. Here is a link to the product I use. Oh, another tip, I did have a problem with the normal syringes giving out after one or two legs, so I use AI syringes, they don't have the rubber stopper in them.