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FSGS Information   Discussions

Started 1/3/20 by CDP (PerraultC); 217 views.
CDP (PerraultC)
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From: CDP (PerraultC)

1/3/20

Focal Segmental Glomerulosclerosis (FSGS) is rare but often aggressive disease that presents as nephrotic syndrome.  This is  one of several diseases that fall under the umbrella of nephrotic syndrome, along with others such as Minimal Change Disease, Membranous Nephropathy, and IgA Nephropathy, the latter of  which you may have seen me post about since it's the  disease I was blessed with.

What all these diseases have in common (and defines the condition as nephrotic syndrome) is that the damage they do to your kidneys causes and blood and protein to be spilled into your urine rather than  filtered correctly and returned to the blood  stream. How each of those disease accomplish their  damage is what separates them.

In the case  of FSGS (I won't type or say  the full name any more than absolutely necessary), it seems to come on as a result of the body's immune system attacking the kidneys for no known reason, which causes scarring to sections of some of the glomeruli that act as filters in your kidney. In  that way it is similar to IgAN, but where the former leads to the filters being clogged by clusters of misbehaving proteins, the FSGS scars the filters directly.

There are different variants to FSGS that differ in their severity. While there are no known  causes as to how the disease originates, there are suspected causes, especially  in  the case of secondary  FSGS where the disease comes along as an association  with another primary disease.

You can  read more details on this at the Nephcure site which does a great job presenting information on FSGS (as well as other NS based diseases) and pushing  for advances in NS  related research.

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CDP (PerraultC)
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From: CDP (PerraultC)

1/3/20

In reply toRe: msg 1
CDP (PerraultC)
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From: CDP (PerraultC)

1/3/20

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